Invention Grant
US08119417B2 Monitoring treatment of head and neck cancer patients with drugs EGFR pathway using mass spectrometry of patient samples
有权
使用患者样本的质谱法监测用药物EGFR途径的头颈癌患者的治疗
- Patent Title: Monitoring treatment of head and neck cancer patients with drugs EGFR pathway using mass spectrometry of patient samples
- Patent Title (中): 使用患者样本的质谱法监测用药物EGFR途径的头颈癌患者的治疗
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Application No.: US12931322Application Date: 2011-01-27
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Publication No.: US08119417B2Publication Date: 2012-02-21
- Inventor: Heinrich Röder , Maxim Tsypin , Julia Grigorieva
- Applicant: Heinrich Röder , Maxim Tsypin , Julia Grigorieva
- Applicant Address: US CO Broomfield
- Assignee: Biodesix, Inc.
- Current Assignee: Biodesix, Inc.
- Current Assignee Address: US CO Broomfield
- Agency: McDonell Boehnen Hulbert & Berghoff, LLP
- Main IPC: G01N24/00
- IPC: G01N24/00

Abstract:
Methods using mass spectral data analysis and a classification algorithm provide an ability to determine whether a non-small-cell lung cancer patient, head and neck squamous cell carcinoma or colorectal cancer patient has likely developed a non-responsiveness to treatment with a drug targeting an epidermal growth factor receptor pathway. As the methods of this disclosure require only simple blood samples, the methods enable a fast and non-intrusive way of measuring when drugs targeting the EGFR pathway cease to be effective in certain patients. This discovery represents the first known example of true personalized selection of these types of cancer patients for treatment using these classes of drugs not only initially, but during the course of treatment.
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