Invention Grant
US08119642B2 Structurally rigid dopamine D3 receptor selective ligands and process for making them
有权
结构刚性多巴胺D3受体选择性配体及其制备方法
- Patent Title: Structurally rigid dopamine D3 receptor selective ligands and process for making them
- Patent Title (中): 结构刚性多巴胺D3受体选择性配体及其制备方法
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Application No.: US12558983Application Date: 2009-09-14
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Publication No.: US08119642B2Publication Date: 2012-02-21
- Inventor: Amy Newman , Peter Grundt , Robert R. Luedtke
- Applicant: Amy Newman , Peter Grundt , Robert R. Luedtke
- Applicant Address: US DC Washington US TX Fort Worth
- Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services,University of North Texas Health Science Center at Fort Worth
- Current Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services,University of North Texas Health Science Center at Fort Worth
- Current Assignee Address: US DC Washington US TX Fort Worth
- Agency: Cantor Colburn LLP
- Main IPC: A61K31/4965
- IPC: A61K31/4965 ; C07D295/00

Abstract:
A family of structurally rigid dopamine D3 receptor selective ligands is described. The family of structurally rigid dopamine D3 receptor selective ligands has the formula wherein A is cis or trans —CH═CH—, —C═C—, or cyclohexyl. B is cis or trans —CH═CH— or absent. R1 represents an optionally substituted phenyl group, wherein said substituents are selected from the group consisting of: hydrogen, halogen, amino, nitro, hydroxyl, alkoxy, alkyl, acyl and pyridyl, and said substitution may occur at any of the ortho, meta, or para positions, or R1 represents a heteroaromatic ring. A preferred heteroaromatic ring is indole, quinoxoline, pyridyl, pyrimidyl, or imidazole. R2 and R3 may be independently hydrogen or a halogen, or R2 alone may be C1, C2, or C3 alkoxy, and m is 1 or 2, and n is 0, 1, or 2.
Public/Granted literature
- US20100068138A1 STRUCTURALLY RIGID DOPAMINE D3 RECEPTOR SELECTIVE LIGANDS AND PROCESS FOR MAKING THEM Public/Granted day:2010-03-18
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