Invention Grant
US08119768B2 Compositions and methods for modulating AMPA receptor-mediated excitotoxicity
有权
用于调节AMPA受体介导的兴奋性毒性的组合物和方法
- Patent Title: Compositions and methods for modulating AMPA receptor-mediated excitotoxicity
- Patent Title (中): 用于调节AMPA受体介导的兴奋性毒性的组合物和方法
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Application No.: US12310558Application Date: 2007-08-31
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Publication No.: US08119768B2Publication Date: 2012-02-21
- Inventor: Fang Liu
- Applicant: Fang Liu
- Applicant Address: CA Toronto
- Assignee: Centre for Addiction and Mental Health
- Current Assignee: Centre for Addiction and Mental Health
- Current Assignee Address: CA Toronto
- International Application: PCT/CA2007/001539 WO 20070831
- International Announcement: WO2008/025163 WO 20080306
- Main IPC: A61K38/00
- IPC: A61K38/00 ; C07K14/00
Abstract:
The present invention provides AMPAR excitotoxicity mediating polypeptides comprising the GluR2 NT1-3-2 (Y142-K172) amino acid sequence (SEQ ID NO:1) or the GAPDH(2-2-1-1) (I221-E250) amino acid sequence (SEQ ID NO:2). Also disclosed are nucleotide sequences encoding the polypeptides, methods of inhibiting GAPDH association with the GluR2 subunit or p53. Methods of inhibiting AMPA receptor mediated excitotoxicity using the polypeptides and nucleic acids are also disclosed.
Public/Granted literature
- US20100210521A1 Compositions and methods for modulating ampa receptor-mediated excitotoxicity Public/Granted day:2010-08-19
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