Invention Grant
- Patent Title: Cicletanine derivatives
- Patent Title (中): 花氨酸衍生物
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Application No.: US12509698Application Date: 2009-07-27
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Publication No.: US08119806B2Publication Date: 2012-02-21
- Inventor: Amjad Ali , Iyassu K. Sebhat , Christopher L. Franklin , Kathleen M. Rupprecht , Robert K. Baker , Ravi P. Nargund , Lin Yan , Pei Huo , Dong-Ming Shen , Nicoletta Almirante , Stefano Biondi , Massimiliano Ferrario , Alessia Nicotra
- Applicant: Amjad Ali , Iyassu K. Sebhat , Christopher L. Franklin , Kathleen M. Rupprecht , Robert K. Baker , Ravi P. Nargund , Lin Yan , Pei Huo , Dong-Ming Shen , Nicoletta Almirante , Stefano Biondi , Massimiliano Ferrario , Alessia Nicotra
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Richard S. Parr; Catherine D. Fitch; Mark R. Daniel
- Main IPC: A61K31/4355
- IPC: A61K31/4355 ; C07D491/048
Abstract:
A compound having the structure wherein X is selected from the group consisting of: a bond, —NHCH2(CH2)nCH2OC(O)—, —CH2NHC(O)CH2NHC(O)—, —CH2OC(O)—, —OCH(CH3)OC(O)—, —OCH2OC(O)—, —O—, —NR1—, —CR1R3—, —(CH2)p—, —(CH2)qNR1C(O)—, —CHR5NR2C(O)—, —(CH2)qC(O)—, —(CH2)qC(O)NR1—, or a pharmaceutically acceptable salt thereof, and methods of using the compounds for treating hypertension.
Public/Granted literature
- US20100029678A1 DIURETICS Public/Granted day:2010-02-04
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