Invention Grant
US08119835B2 Method for preparation of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphtoic acid
失效
6- [3-（1-金刚烷基）-4-甲氧基苯基] -2-萘甲酸的制备方法
![Method for preparation of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphtoic acid](/docs/US/2012-02-21/US08119835B2/abs.jpg.600x600.jpg)
- Patent Title: Method for preparation of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphtoic acid
- Patent Title (中): 6- [3-（1-金刚烷基）-4-甲氧基苯基] -2-萘甲酸的制备方法
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Application No.: US12448672Application Date: 2007-12-28
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Publication No.: US08119835B2Publication Date: 2012-02-21
- Inventor: Ivars Kalvinsh , Aleksandrs Chernobrovijs , Vyacheslav Tribulovich , Vladimir Labeish
- Applicant: Ivars Kalvinsh , Aleksandrs Chernobrovijs , Vyacheslav Tribulovich , Vladimir Labeish
- Applicant Address: LV Riga
- Assignee: JSC Grindeks
- Current Assignee: JSC Grindeks
- Current Assignee Address: LV Riga
- Agency: Hueschen and Sage
- Priority: LVP-06-149 20061228
- International Application: PCT/EP2007/064643 WO 20071228
- International Announcement: WO2008/086942 WO 20080724
- Main IPC: C07C63/34
- IPC: C07C63/34 ; C07C69/76
![Method for preparation of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphtoic acid](/abs-image/US/2012/02/21/US08119835B2/abs.jpg.150x150.jpg)
Abstract:
A method for preparation of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid is disclosed based on “one pot” synthesis approach including a direct synthesis of boronic acid derivative from 2-(1-adamantyl)-4-bromoanisole and cycloboranes with a subsequent Suzuki-Miyaura coupling with 6-halonaphtenoates and basic hydrolysis of the reaction product in ethylene glycol or 1,2-propanediol.
Public/Granted literature
- US20100076219A1 METHOD FOR PREPARATION OF 6-[3(1-ADAMANTYL) -4-METHOXYPHENYL]-2-NAPHTOIC ACID Public/Granted day:2010-03-25
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