A method and apparatus for hopping of a Code Division Multiple Access (CDMA) control segment that carries control information in an Orthogonal Frequency Division Multiple Access (OFDMA) packet data mobile communication system are provided, in which a number of CDMA control segment hopping zones, each CDMA control segment hopping zone representing a frequency area for CDMA control segment hopping, is determined according to a total number of available tiles in the system and a number of tiles per CDMA control segment, each tile including a predetermined number of subcarriers, or according to a total number of available subcarriers in the system and a number of subcarriers per CDMA control segment. Start points of the hopping zones are determined using the number of the hopping zones, and the control information is transmitted or received in the CDMA control segment through hopping of the CDMA control segment over the hopping zones using the start points.