Communication between microchannels of a microfluidic circuit is controlled through a combination between a membrane and a pin-actuated valve arrangement. The deformable membrane contributes to the formation of the surface of the microchannels. Alternatively, or in addition, the valve arrangement is operated through combination of the membrane with a control fluid. Systems, devices and methods based on such communication are shown. Also shown are methods to manufacture a system having a fluidic circuit and a control arrangement.