Invention Grant
- Patent Title: Chimeric plasminogen activators and their pharmaceutical use
- Patent Title (中): 嵌合型纤溶酶原激活剂及其药物用途
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Application No.: US10583785Application Date: 2003-12-18
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Publication No.: US08124588B2Publication Date: 2012-02-28
- Inventor: Werner Seeger , Andreas Günther , Clemens Ruppert , Philipp Markart , Viktor Magdolen , Timothy E. Weaver
- Applicant: Werner Seeger , Andreas Günther , Clemens Ruppert , Philipp Markart , Viktor Magdolen , Timothy E. Weaver
- Applicant Address: DE Giessen
- Assignee: Justus Liebig Universität Giessen
- Current Assignee: Justus Liebig Universität Giessen
- Current Assignee Address: DE Giessen
- Agency: Acuity Law Group, P.C.
- Agent Michael A. Whittaker
- International Application: PCT/EP03/14542 WO 20031218
- International Announcement: WO2005/059142 WO 20050630
- Main IPC: A61K38/17
- IPC: A61K38/17 ; C07K14/435 ; C07H21/04 ; C12N15/63
Abstract:
The present invention relates to recombinant chimeric proteins comprising a surfactant protein precursor N-terminally fused to a plasminogen activator or comprising a mature surfactant protein N-terminally or C-terminally fused to a plasminogen activator. The invention is also directed to the corresponding nucleic acid molecules encoding such fusion proteins as well as to a method for their production. The invention further refers to a pharmaceutical composition comprising such a fusion protein and to pharmacological uses of an inventive fusion protein for the prevention and/or treatment of inflammatory and interstitial lung diseases.
Public/Granted literature
- US20090305961A1 Novel chimeric plasminogen activators and their pharmaceutical use Public/Granted day:2009-12-10
Information query
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