Invention Grant
- Patent Title: Synthesis of 4/5-pyrimidinylimidazoles via sequential functionalization of 2,4-dichloropyrimidine
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Application No.: US12830998Application Date: 2010-07-06
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Publication No.: US08124765B2Publication Date: 2012-02-28
- Inventor: Xiaohu Deng , Neelakandha Mani
- Applicant: Xiaohu Deng , Neelakandha Mani
- Applicant Address: BE Beerse
- Assignee: Janssen Pharmaceutica, NV
- Current Assignee: Janssen Pharmaceutica, NV
- Current Assignee Address: BE Beerse
- Main IPC: C07D401/00
- IPC: C07D401/00 ; C07D403/00 ; C07D405/00 ; C07D409/00 ; C07D411/00 ; C07D413/00 ; C07D417/00 ; C07D419/00
Abstract:
This invention relates to methods of making pyrimidinyl-substituted imidazole compounds by sequential substitution of the 4- and 2-chloro groups of 2,4-dichloropyrimidine, nucleophilic substitution to form pyrimidinylalkyne derivatives, oxidation to the corresponding 1,2-diketones, and cyclocondensation reactions.
Public/Granted literature
- US20100274015A1 SYNTHESIS OF 4/5-PYRIMIDINYLIMIDAZOLES VIA SEQUENTIAL FUNCTIONALIZATION OF 2,4-DICHLOROPYRIMIDINE Public/Granted day:2010-10-28
Information query
