Systems and methods are provided for evaluating the risk of stress-related injury associated with a predetermined activity. One embodiment involves collecting physiological data while a subject performs a predetermined task, collecting psychological data while the subject performs a cognitive task, and ascertaining the risk of stress-related injury based on both the collected physiological data and the collected psychological data. Another embodiment involves presenting a subject with a plurality of mental and physical tasks during which physiological data, psychological data, and/or both is collected, and determining the risk of stress-related injury based on the data collected. Yet another embodiment includes a test circuit for measuring stress responses that includes both physiological test stations and psychological test stations. Physiological stress is evaluated in the form of surface electromyography data that is quantified into a single index value, as will be described in detail herein.