Removable cartridge storage devices and methods are disclosed. In one embodiment, the removable cartridge storage device comprises a plurality of cartridge holders, each of the cartridge holders including an electrical connector configured to removably couple with a mating electrical connector of a portable data cartridge having an electronic interface, a system controller configured to control data operations, and a switch, coupled between the cartridge holders and the system controller, to electronically switch connections between the system controller and each of the cartridge holders.