Tooling assemblies for interfacing with interchangeable molds are provided, each with a tooling body for mounting to a platen of a press of an injection molding machine and for receiving an interchangeable mold block. Interchangeable mold blocks are also provided for forming articles. A series of fasteners fasten each mold block to one of the tooling bodies. Alignment systems are oriented within a perimeter of the mold block to permit expansion of the mold block relative to the tooling body to accommodate varying rates of thermal expansion of the tooling body and the mold block. Methods for assembling a mold, molding an article and interchanging a mold with interchangeable mold blocks are also provided.