A pressure connection device for a guidewire unit that is operated with a pressure medium is provided. A return valve is mounted in the interior of a tube end section of a pressure medium tube of the guidewire unit, the return valve opening for introducing the pressure medium into the pressure medium tube and closing in order to prevent the pressure medium from escaping from the pressure medium tube, and/or a connecting body accommodates the tube end section of the pressure medium tube and has a pressure medium-controlled tube holding element which secures the tube end section to the connecting body in a fluid-tight manner when impinged upon with pressure and, in a pressure-relieved state, releases it so it can be detached from the connecting body.