In one embodiment, a handheld microdermabrasion device includes a treatment head and a motor for driving, e.g., oscillating or rotating, the treatment head to abrade or exfoliate the skin. The treatment head may be abrasive or non-abrasive, and includes a passage or opening in communication with a reservoir for containing a topical solution. As the skin is abraded by the treatment head, the topical solution from the reservoir is automatically dispensed through the opening in the treatment head. In some embodiments, the motor which drives the treatment head also drives a pump for moving fluid from the reservoir and through the treatment head. The topical solution may be abrasive or non-abrasive. In some embodiments, the topical solution is a therapeutic solution for treating the skin.