Invention Grant
US08128921B2 Use of conditional plasmodium strains lacking nutrient transporters in malaria vaccination
有权
在疟疾疫苗接种中使用缺乏营养转运蛋白的条件疟原虫菌株
- Patent Title: Use of conditional plasmodium strains lacking nutrient transporters in malaria vaccination
- Patent Title (中): 在疟疾疫苗接种中使用缺乏营养转运蛋白的条件疟原虫菌株
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Application No.: US11827282Application Date: 2007-07-11
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Publication No.: US08128921B2Publication Date: 2012-03-06
- Inventor: Choukri Ben Mamoun , Kamal El Bissati
- Applicant: Choukri Ben Mamoun , Kamal El Bissati
- Applicant Address: US CT Farmington
- Assignee: University of Connecticut
- Current Assignee: University of Connecticut
- Current Assignee Address: US CT Farmington
- Agency: Kilpatrick, Townsend & Stockton LLP
- Main IPC: A01N63/00
- IPC: A01N63/00 ; A01N65/00 ; A61K48/00 ; A61K39/38
Abstract:
The present invention relates to a malaria vaccine for administration to a host comprising an attenuated malarial parasite with a gene which has been rendered non-functional, wherein the gene, when present in naturally occurring form, encodes a protein necessary for continued in vivo survival and proliferation of the parasite and for infection of host red blood cells. The invention further relates to a malaria vaccine in which a gene that encodes a nutrient transporter protein has been rendered non-functional.
Public/Granted literature
- US20080026010A1 Use of conditional plasmodium strains lacking nutrient transporters in malaria vaccination Public/Granted day:2008-01-31
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