Invention Grant
- Patent Title: Anti-ADDL antibodies and uses thereof
- Patent Title (中): 抗ADDL抗体及其用途
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Application No.: US12828411Application Date: 2010-07-01
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Publication No.: US08128930B2Publication Date: 2012-03-06
- Inventor: Paul Acton , Zhiqiang An , Andrew J. Bett , Robert Breese , Lei Chang , Elizabeth Chen Dodson , Gene Kinney , William L. Klein , Mary P. Lambert , Xiaoping Liang , Paul Shughrue , William R. Strohl , Kristen Viola
- Applicant: Paul Acton , Zhiqiang An , Andrew J. Bett , Robert Breese , Lei Chang , Elizabeth Chen Dodson , Gene Kinney , William L. Klein , Mary P. Lambert , Xiaoping Liang , Paul Shughrue , William R. Strohl , Kristen Viola
- Applicant Address: US IL Evanston US NJ Rahway
- Assignee: Northwestern University,Merck Sharp & Dohme Corp.
- Current Assignee: Northwestern University,Merck Sharp & Dohme Corp.
- Current Assignee Address: US IL Evanston US NJ Rahway
- Agency: Licata & Tyrrell P.C.
- Main IPC: A61K39/395
- IPC: A61K39/395 ; C07K16/18 ; G01N33/53
Abstract:
The present invention relates to antibodies that differentially recognize multi-dimensional conformations of Aβ-derived diffusible ligands, also known as ADDLs. The antibodies of the invention can distinguish between Alzheimer's Disease and control human brain extracts and are useful in methods of detecting ADDLs and diagnosing Alzheimer's Disease. The present antibodies also block binding of ADDLs to neurons, assembly of ADDLs, and tau phosphorylation and are there useful in methods for the preventing and treating diseases associated with soluble oligomers of amyloid β 1-42.
Public/Granted literature
- US20100272714A1 Anti-ADDL Antibodies and Uses Thereof Public/Granted day:2010-10-28
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