Invention Grant
- Patent Title: Method for treatment or prevention of disease associated with functional disorder of regulatory T cell
- Patent Title (中): 治疗或预防与调节性T细胞功能紊乱相关的疾病的方法
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Application No.: US12084907Application Date: 2006-11-14
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Publication No.: US08128934B2Publication Date: 2012-03-06
- Inventor: Akio Suzumura , Jinyan Wang , Takashi Matsui , Sadatoshi Sakuma , Shin Miyakawa , Masatoshi Fujiwara , Yoshikazu Nakamura
- Applicant: Akio Suzumura , Jinyan Wang , Takashi Matsui , Sadatoshi Sakuma , Shin Miyakawa , Masatoshi Fujiwara , Yoshikazu Nakamura
- Applicant Address: JP Tokyo AU Sydney
- Assignee: Ribomic, Inc.,Cellmid Limited
- Current Assignee: Ribomic, Inc.,Cellmid Limited
- Current Assignee Address: JP Tokyo AU Sydney
- Agency: Wenderoth, Lind & Ponack, LLP
- Priority: JP2005-329418 20051114
- International Application: PCT/JP2006/322659 WO 20061114
- International Announcement: WO2007/055378 WO 20070518
- Main IPC: A61K39/395
- IPC: A61K39/395 ; C07K16/22
Abstract:
The inventors examined the role of MK in experimental autoimmune encephalomyelitis, which is a human model for multiple sclerosis. As a result, they discovered that MK has the effect of inhibiting regulatory T cells, and that the autoimmune mechanism induced by type 1 helper T cells can be suppressed by inhibiting MK expression or its activity, thereby increasing the number of regulatory T cells. Furthermore, it was found that diseases associated with the functional disorder of regulatory T cells can be treated with the administration of an inhibitor that inhibits MK expression or activity.
Public/Granted literature
- US20100092488A1 Method for Treatment or Prevention of Disease Associated Wtih Functional Disorder of Regulatory T Cell Public/Granted day:2010-04-15
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