Invention Grant
US08128940B2 Modified clostridial toxins with enhanced targeting capabilities for endogenous clostridial toxin receptor systems
有权
改良的梭菌毒素具有增强的内源性梭菌毒素受体系统的靶向能力
- Patent Title: Modified clostridial toxins with enhanced targeting capabilities for endogenous clostridial toxin receptor systems
- Patent Title (中): 改良的梭菌毒素具有增强的内源性梭菌毒素受体系统的靶向能力
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Application No.: US11908349Application Date: 2006-03-14
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Publication No.: US08128940B2Publication Date: 2012-03-06
- Inventor: Lance E. Steward , Ester Fernandez-Salas , Joseph Francis , Shengwen Li , Marcella A. Gilmore , Kei R. Aoki
- Applicant: Lance E. Steward , Ester Fernandez-Salas , Joseph Francis , Shengwen Li , Marcella A. Gilmore , Kei R. Aoki
- Applicant Address: US CA Irvine
- Assignee: Allergan, Inc.
- Current Assignee: Allergan, Inc.
- Current Assignee Address: US CA Irvine
- Agent Kenton Abel; Debra Condino
- International Application: PCT/US2006/008956 WO 20060314
- International Announcement: WO2006/101809 WO 20060928
- Main IPC: C07K14/33
- IPC: C07K14/33 ; C12N15/62 ; C07H21/04
Abstract:
The specification discloses modified Clostridial toxins comprising a Clostridial toxin enzymatic domain, a Clostridial toxin translocation domain and an enhanced Clostridial toxin binding domain; polynucleotide molecules encoding such modified Clostridial toxins; and method of producing such modified Clostridial toxins.
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