Invention Grant
US08128944B2 RNA sequence motifs in the context of defined internucleotide linkages inducing specific immune modulatory profiles
有权
RNA序列基序在定义的核苷酸间键的背景下诱导特异性免疫调节谱
- Patent Title: RNA sequence motifs in the context of defined internucleotide linkages inducing specific immune modulatory profiles
- Patent Title (中): RNA序列基序在定义的核苷酸间键的背景下诱导特异性免疫调节谱
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Application No.: US12670697Application Date: 2008-08-08
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Publication No.: US08128944B2Publication Date: 2012-03-06
- Inventor: Marion Jurk , Jorg Vollmer
- Applicant: Marion Jurk , Jorg Vollmer
- Applicant Address: DE Dusseldorf
- Assignee: Coley Pharmaceutical GmbH
- Current Assignee: Coley Pharmaceutical GmbH
- Current Assignee Address: DE Dusseldorf
- Agent Paul M. Misiak
- International Application: PCT/IB2008/002104 WO 20080808
- International Announcement: WO2009/022216 WO 20090219
- Main IPC: A61K47/00
- IPC: A61K47/00 ; A61K31/00 ; C07H21/04
Abstract:
Immunostimulatory polymers that contain certain sequence-dependent immunostimulatory RNA motifs and methods for the use of such immunostimulatory polymers and compositions containing such polymers are provided according to the invention. The sequence-dependent immunostimulatory RNA motifs and the polymers incorporating such motifs are potent and selective inducers of TLR7 and the TLR7-associated cytokine IFN-α.
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