Invention Grant
- Patent Title: Method and apparatus for the non-invasive measurement of tissue function and metabolism by determination of steady-state fluorescence anisotropy
- Patent Title (中): 通过测定稳态荧光各向异性来非组织测量组织功能和代谢的方法和装置
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Application No.: US11624820Application Date: 2007-01-19
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Publication No.: US08129105B2Publication Date: 2012-03-06
- Inventor: Ralph Zuckerman
- Applicant: Ralph Zuckerman
- Applicant Address: US PA Philadelphia
- Assignee: Ralph Zuckerman
- Current Assignee: Ralph Zuckerman
- Current Assignee Address: US PA Philadelphia
- Agency: Knobbe Martens Olson & Bear LLP
- Main IPC: C12Q1/00
- IPC: C12Q1/00
Abstract:
A non-invasive measurement of biological tissue reveals information about the function of that tissue. Polarized light is directed onto the tissue, stimulating the emission of fluorescence, due to one or more endogenous fluorophors in the tissue. Fluorescence anisotropy is then calculated. Such measurements of fluorescence anisotropy are then used to assess the functional status of the tissue, and to identify the existence and severity of disease states. Such assessment can be made by comparing a fluorescence anisotropy profile with a known profile of a control.
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