Invention Grant
US08129112B2 Polymorphisms in the human CYP2D6 gene promoter region and their use in diagnostic and therapeutic applications
有权
人CYP2D6基因启动子区域的多态性及其在诊断和治疗应用中的应用
- Patent Title: Polymorphisms in the human CYP2D6 gene promoter region and their use in diagnostic and therapeutic applications
- Patent Title (中): 人CYP2D6基因启动子区域的多态性及其在诊断和治疗应用中的应用
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Application No.: US10182977Application Date: 2001-01-30
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Publication No.: US08129112B2Publication Date: 2012-03-06
- Inventor: Sebastian Raimundo , Ulrich Zanger
- Applicant: Sebastian Raimundo , Ulrich Zanger
- Applicant Address: US MA Newton
- Assignee: PGxHealth, LLC
- Current Assignee: PGxHealth, LLC
- Current Assignee Address: US MA Newton
- Agency: McCarter & English, LLP
- Priority: EP00101889 20000131
- International Application: PCT/EP01/00954 WO 20010130
- International Announcement: WO01/55432 WO 20010802
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; C07H21/04 ; C12P19/34
Abstract:
Provided are polynucleotides of molecular variant promoters of the CYP2D6 gene which, for example, are associated with abnormal drug response or individual predisposition to several common diseases and disorders caused by drug under- or over-metabolization, and vectors comprising such polynucleotides. Furthermore, methods of diagnosing the status of disorders related to intermediate metabolization of drugs are described. In addition, kits comprising oligonucleotides hybridizing to the CYP2D6 promoter and/or being capable of being extended into this region useful for diagnosing subjects that are ultrarapid or intermediate metabolizer of drugs are provided.
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