Invention Grant
US08129121B2 Regulation of lipid droplet formation by modulation of FIT1 and FIT2 and uses thereof
失效
通过调节FIT1和FIT2调节脂滴形成及其用途
- Patent Title: Regulation of lipid droplet formation by modulation of FIT1 and FIT2 and uses thereof
- Patent Title (中): 通过调节FIT1和FIT2调节脂滴形成及其用途
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Application No.: US12448840Application Date: 2008-01-08
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Publication No.: US08129121B2Publication Date: 2012-03-06
- Inventor: David L. Silver
- Applicant: David L. Silver
- Applicant Address: US NY Bronx US NY New York
- Assignee: Albert Einstein College of Medicine of Yeshiva University,The Trustees of Columbia University in the City of New York
- Current Assignee: Albert Einstein College of Medicine of Yeshiva University,The Trustees of Columbia University in the City of New York
- Current Assignee Address: US NY Bronx US NY New York
- Agency: Amster, Rothstein & Ebenstein LLP
- International Application: PCT/US2008/000258 WO 20080108
- International Announcement: WO2008/088694 WO 20080724
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; A61K51/00 ; C12N15/11
Abstract:
This invention provides methods of regulating fat storage in tissue by modulating the levels of Fibrate Induced Transcript 1 (FIT1) and/or Fibrate Induced Transcript 2 (FIT2), as well as diagnostic screens for disorders and conditions involving regulation of fat storage in tissue, assays for identifying agents that can regulate fat storage in tissue through modulating the levels of FIT1 and/or FIT2, and genetically altered mammals in which expression of FIT1 and/or FIT2 is altered in one or more tissue.
Public/Granted literature
- US20100095391A1 REGULATION OF LIPID DROPLET FORMATION BY MODULATION OF FIT1 AND FIT2 AND USES THEREOF Public/Granted day:2010-04-15
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