Invention Grant
US08129124B2 Agents and methods related to reducing resistance to apoptosis-inducing death receptor agonists
有权
与降低细胞凋亡诱导死亡受体激动剂抗性有关的药物和方法
- Patent Title: Agents and methods related to reducing resistance to apoptosis-inducing death receptor agonists
- Patent Title (中): 与降低细胞凋亡诱导死亡受体激动剂抗性有关的药物和方法
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Application No.: US11814551Application Date: 2006-01-31
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Publication No.: US08129124B2Publication Date: 2012-03-06
- Inventor: Tong Zhou , Robert P. Kimberly
- Applicant: Tong Zhou , Robert P. Kimberly
- Applicant Address: US AL Birmingham
- Assignee: The UAB Research Foundation
- Current Assignee: The UAB Research Foundation
- Current Assignee Address: US AL Birmingham
- Agency: McKeon, Meunier, Carlin & Curfman, LLC
- International Application: PCT/US2006/003503 WO 20060131
- International Announcement: WO2006/083937 WO 20060810
- Main IPC: G01N33/53
- IPC: G01N33/53 ; G01N33/566 ; C07K14/715 ; C07K14/47 ; C07K14/52
Abstract:
Provided herein is a method of reversing or preventing a target cell's resistance to a death receptor agonist. Also provided are methods of screening for biomarkers resistance of and monitoring resistance to death receptor agonists. Also provided are methods of selectively inducing apoptosis in a target cell, treating a subject with cancer, autoimmune or inflammatory diseases, comprising administering compositions provided herein. Further provided are compositions comprising agents that modulate CARD containing proteins.
Public/Granted literature
- US20100135951A1 Agents and Methods Related to Reducing Resistance To Apoptosis-Inducing Death Receptor Agonists Public/Granted day:2010-06-03
Information query
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