Invention Grant
- Patent Title: Methods of cleaving DNA with rationally-designed meganucleases
-
Application No.: US13246270Application Date: 2011-09-27
-
Publication No.: US08129134B2Publication Date: 2012-03-06
- Inventor: James Jefferson Smith , Derek Jantz , Homme W. Hellinga
- Applicant: James Jefferson Smith , Derek Jantz , Homme W. Hellinga
- Applicant Address: US NC Durham
- Assignee: Duke University
- Current Assignee: Duke University
- Current Assignee Address: US NC Durham
- Agency: Pickering Hale and Dorr LLP
- Agent Wilmer Cutler
- Main IPC: C12Q1/34
- IPC: C12Q1/34 ; C12Q1/68 ; C07K14/00 ; C12P21/00 ; C12N9/16
Abstract:
Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment of pathogenic infections, and for in vitro applications in diagnostics and research.
Public/Granted literature
- US20120021520A1 RATIONALLY-DESIGNED MEGANUCLEASES WITH ALTERED SEQUENCE SPECIFICITY AND DNA-BINDING AFFINITY Public/Granted day:2012-01-26
Information query
