Invention Grant
- Patent Title: Ketol-acid reductoisomerase using NADH
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Application No.: US12337736Application Date: 2008-12-18
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Publication No.: US08129162B2Publication Date: 2012-03-06
- Inventor: Yougen Li , Der-Ing Liao , Mark J. Nelson , Daniel P. Okeefe
- Applicant: Yougen Li , Der-Ing Liao , Mark J. Nelson , Daniel P. Okeefe
- Applicant Address: US DE Wilmington
- Assignee: Butamax(TM) Advanced Biofuels LLC
- Current Assignee: Butamax(TM) Advanced Biofuels LLC
- Current Assignee Address: US DE Wilmington
- Agent Christine M. Lhulier
- Main IPC: C12N9/02
- IPC: C12N9/02 ; C12N15/00 ; C12P21/06 ; C12P21/04 ; C07H21/04
Abstract:
Methods for the evolution of NADPH binding ketol-acid reductoisomerase enzymes to acquire NADH binding functionality are provided. Specific mutant ketol-acid reductoisomerase enzymes isolated from Pseudomonas that have undergone co-factor switching to bind NADH are described.
Public/Granted literature
- US20090163376A1 KETOL-ACID REDUCTOISOMERASE USING NADH Public/Granted day:2009-06-25
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