The present invention relates to an indicator of sterilization and/or use, which may be affixed to or integrated in a limited use device. The indicator may include a plurality of layers wherein each of the layers includes a membrane. The indictor may also include indicia of the number of uses disposed between the layers. The membranes may breach upon the sterilization or use of the limited use device, wherein the device is exposed to a given environment, such as various gasses, steam, liquids, UV, plasma, etc. In addition, more than one membrane may be provided between each indicia, wherein each membrane may respond to a different environment.