A method of manufacturing a semiconductor device, includes forming an insulating film of a material having a low relative dielectric constant on a substrate, forming an SiOCH film on the insulating film in a chamber, forming an SiO2 film continuously on the SiOCH film by reducing a carbon concentration therein in the chamber in which plasma is being generated, performing a plasma etching on the insulating film by using the SiOCH film and the SiO2 film as a hardmask layer, to form a trench in the insulating film, and performing wet etching on a surface of the trench formed in the insulating film, to remove a layer damaged by the plasma etching and process residues.