Invention Grant
- Patent Title: Nitric oxide-blocked cross-linked tetrameric hemoglobin
- Patent Title (中): 一氧化氮封闭交联的四聚体血红蛋白
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Application No.: US12287558Application Date: 2008-10-10
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Publication No.: US08129338B2Publication Date: 2012-03-06
- Inventor: Ross Walden Tye
- Applicant: Ross Walden Tye
- Applicant Address: US SD Aberdeen
- Assignee: IKOR, Inc.
- Current Assignee: IKOR, Inc.
- Current Assignee Address: US SD Aberdeen
- Agency: Fliesler Meyer LLP
- Main IPC: C07K14/00
- IPC: C07K14/00
Abstract:
The present invention includes compositions containing carboxamidomethylated cross-linked hemoglobin where the cysteine moiety of the hemoglobin includes a thiol protecting group and where the hemoglobin has a reduced ability to bind with nitric oxide. Preferably, the hemoglobin is deoxygenated, endotoxin free, and stroma free. The present invention also includes method of preparation, process of preparation and the method of use including supplementing blood volume in mammals and treating disorders in mammals where oxygen delivery agents are of benefit.
Public/Granted literature
- US20100035797A1 Nitric oxide-blocked cross-linked tetrameric hemoglobin Public/Granted day:2010-02-11
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