Invention Grant
US08129340B2 Inhibitors of protein phosphatase 1, GADD34 and protein phosphatase 1/GADD34 complex, preparation and uses thereof
失效
蛋白磷酸酶1，GADD34和蛋白磷酸酶1 / GADD34复合物的抑制剂，其制备和用途
- Patent Title: Inhibitors of protein phosphatase 1, GADD34 and protein phosphatase 1/GADD34 complex, preparation and uses thereof
- Patent Title (中): 蛋白磷酸酶1，GADD34和蛋白磷酸酶1 / GADD34复合物的抑制剂，其制备和用途
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Application No.: US12438833Application Date: 2007-09-07
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Publication No.: US08129340B2Publication Date: 2012-03-06
- Inventor: Guido Kroemer , Laurence Zitvogel
- Applicant: Guido Kroemer , Laurence Zitvogel
- Applicant Address: FR Villejuif Cedex FR Paris Cedex
- Assignee: Institut Gustave Roussy,Institut National de la Sante et de la Recherche Medicale (Inserm)
- Current Assignee: Institut Gustave Roussy,Institut National de la Sante et de la Recherche Medicale (Inserm)
- Current Assignee Address: FR Villejuif Cedex FR Paris Cedex
- Agency: Saliwanchik, Lloyd & Eisenschenk
- Priority: EP06291427 20060908; EP07300806 20070221
- International Application: PCT/EP2007/059409 WO 20070907
- International Announcement: WO2008/028965 WO 20080313
- Main IPC: A61K31/675
- IPC: A61K31/675 ; A61K38/10
Abstract:
The present invention relates to the use of a protein phosphatase inhibitor selected from an inhibitor of the catalytic subunit of the protein phosphatase 1 (PP1), an inhibitor of GADD34 and an inhibitor of the PP1/GADD34 complex to prepare a pharmaceutical composition to prevent or treat a cancer in a mammal, wherein the pharmaceutical composition is intended for administration in combination with a product used in a treatment of a cancer.
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