Invention Grant
- Patent Title: VLA-4 inhibitory drug
- Patent Title (中): VLA-4抑制药
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Application No.: US12097269Application Date: 2006-12-13
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Publication No.: US08129366B2Publication Date: 2012-03-06
- Inventor: Nobuo Machinaga , Shin Iimura , Yoshiyuki Yoneda , Jun Chiba , Fumihito Muro , Hideko Hoh , Atsushi Nakayama
- Applicant: Nobuo Machinaga , Shin Iimura , Yoshiyuki Yoneda , Jun Chiba , Fumihito Muro , Hideko Hoh , Atsushi Nakayama
- Applicant Address: JP Tokyo
- Assignee: Daiichi Sankyo Company, Limited
- Current Assignee: Daiichi Sankyo Company, Limited
- Current Assignee Address: JP Tokyo
- Agency: Oblon, Spivak, McClelland, Maier & Neustadt, L.L.P.
- Priority: JP2005-358523 20051213
- International Application: PCT/JP2006/324825 WO 20061213
- International Announcement: WO2007/069635 WO 20070621
- Main IPC: A61K31/553
- IPC: A61K31/553 ; C07D243/08

Abstract:
There is provided a VLA-4 inhibitory drug having good oral absorbability and exhibiting sufficient anti-inflammatory effects when administered orally.A compound represented by the following formula (I): wherein R1 represents a hydrogen atom or a C1-8 alkyl group; R2 represents a hydrogen atom, a halogen atom, a C1-8 alkoxy group, or a benzyloxy group which may be substituted; Q represents a monocyclic or bicyclic nitrogen-containing heterocyclic group which may be substituted, and has a nitrogen atom as the bonding site; Y represents an oxygen atom or CH2; W represents a bicyclic aromatic hydrocarbon ring group which may be substituted, or a bicyclic aromatic heterocyclic group which may be substituted; R3a, R3b and R3c each independently represent a hydrogen atom, a halogen atom, a C1-8 alkoxy group or a C1-8 alkyl group; and A1 represents a nitrogen atom or C—R3d (wherein R3d represents a hydrogen atom, a halogen atom, a C1-8 alkoxy group or a C1-8 alkyl group), or a salt thereof, or a VLA-4 inhibitory drug comprising the compound or the salt as an active ingredient.
Public/Granted literature
- US20090233901A1 VLA-4 INHIBITORY DRUG Public/Granted day:2009-09-17
Information query
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