Invention Grant
US08129385B2 Substituted 5-hydroxy-3,4,6,9,9a, 10-hexanhydro-2h-1-oxa04a,8a-diaza-anthracene-6,10-dioness
有权
取代的5-羟基-3,4,6,9,9a，10-六氢-2h-1-氧杂-4a，8a-二氮杂 - 蒽-6,10-二酮
- Patent Title: Substituted 5-hydroxy-3,4,6,9,9a, 10-hexanhydro-2h-1-oxa04a,8a-diaza-anthracene-6,10-dioness
- Patent Title (中): 取代的5-羟基-3,4,6,9,9a，10-六氢-2h-1-氧杂-4a，8a-二氮杂 - 蒽-6,10-二酮
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Application No.: US11919386Application Date: 2006-04-28
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Publication No.: US08129385B2Publication Date: 2012-03-06
- Inventor: Brian Alvin Johns , Takashi Kawasuji , Teruhiko Taishi , Yoshiyuki Taoda
- Applicant: Brian Alvin Johns , Takashi Kawasuji , Teruhiko Taishi , Yoshiyuki Taoda
- Applicant Address: JP Osaka US PA Philadelphia
- Assignee: Shionogi & Co., Ltd.,GlaxoSmithKline LLC
- Current Assignee: Shionogi & Co., Ltd.,GlaxoSmithKline LLC
- Current Assignee Address: JP Osaka US PA Philadelphia
- Agency: Wenderoth, Lind & Ponack, L.L.P.
- Priority: JP2005-131161 20050428; JP2005-312076 20051027
- International Application: PCT/US2006/016604 WO 20060428
- International Announcement: WO2006/116764 WO 20061102
- Main IPC: A61K31/495
- IPC: A61K31/495
Abstract:
The present invention is directed to a class of substituted 5-hydroxy-3,4,6,9,9a,10-hexahydro-2H-1-oxa-4a,8a-diaza-anthracene-6,10-diones useful as anti-HIV agents. The compounds have the formula: Z═O; R20, R21, R22, R23, R24 and R25 independently are hydrogen, C1-C8 alkyl, (C6-C14)aryl-(C1-C8)alkyl, C6-C14 aryl, or alkoxy; the stereochemistry of an asymmetric carbon represented by * shows R- or S-configuration, or a mixture thereof; RX is hydrogen; R14 is hydrogen or optionally substituted lower alkyl; R3 is hydrogen; R1 is hydrogen or lower alkyl; R is halogen; and m is 1, 2 or 3; or a pharmaceutically acceptable salt thereof.
Public/Granted literature
- US20090318421A1 Polycyclic carbamoylpyridone derivative having hiv integrase inhibitory activity Public/Granted day:2009-12-24
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