Invention Grant
- Patent Title: Substituted thieno[2,3-d]pyrimidines as AMPA modulators
- Patent Title (中): 取代噻吩并[2,3-d]嘧啶作为AMPA调节剂
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Application No.: US12269306Application Date: 2008-11-12
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Publication No.: US08129397B2Publication Date: 2012-03-06
- Inventor: Michael Gerard Gallagher , Craig C. Jamieson , Amanda Jane Lyons , John Kinnaird Ferguson Maclean , Elizabeth Margaret Moir
- Applicant: Michael Gerard Gallagher , Craig C. Jamieson , Amanda Jane Lyons , John Kinnaird Ferguson Maclean , Elizabeth Margaret Moir
- Applicant Address: US NJ Rahway
- Assignee: MSD Oss B.V.
- Current Assignee: MSD Oss B.V.
- Current Assignee Address: US NJ Rahway
- Agent Susan L. Hess; Gerard M. Devlin
- Priority: EP07120603 20071113
- Main IPC: C07D495/04
- IPC: C07D495/04 ; A61K31/519 ; A61P25/24 ; A61P25/28 ; A61P25/22 ; A61P25/18 ; A61P25/16
![Substituted thieno[2,3-d]pyrimidines as AMPA modulators](/abs-image/US/2012/03/06/US08129397B2/abs.jpg.150x150.jpg)
Abstract:
The present invention relates to a heterocyclic derivative according to formula I wherein the variables are defined as in the specification, or to a pharmaceutically acceptable salt or solvate thereof. The present invention also relates to a pharmaceutical composition comprising said heterocyclic derivatives and to their use in therapy, for instance in the treatment or prevention of psychiatric diseases where an enhancement of synaptic responses mediated by AMPA receptors is required, including schizophrenia, depression and learning and memory disorders such as Alzheimer's disease.
Public/Granted literature
- US20090131455A1 HETEROCYCLIC DERIVATIVES Public/Granted day:2009-05-21
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