Invention Grant
US08129528B2 Method for the use of [11 C] carbon monoxide in labeling synthesis of 11C-labelled amides using metal amides and photo-induced free radical carbonylation
失效
使用[11 C]一氧化碳在金属酰胺标记合成11C标记酰胺和光诱导自由基羰基化的方法
![Method for the use of [11 C] carbon monoxide in labeling synthesis of 11C-labelled amides using metal amides and photo-induced free radical carbonylation](/docs/US/2012-03-06/US08129528B2/abs.jpg.600x600.jpg)
- Patent Title: Method for the use of [11 C] carbon monoxide in labeling synthesis of 11C-labelled amides using metal amides and photo-induced free radical carbonylation
- Patent Title (中): 使用[11 C]一氧化碳在金属酰胺标记合成11C标记酰胺和光诱导自由基羰基化的方法
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Application No.: US12478053Application Date: 2009-06-04
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Publication No.: US08129528B2Publication Date: 2012-03-06
- Inventor: Oleksiy Itsenko , Tor Kihlberg , Bengt Langstrom
- Applicant: Oleksiy Itsenko , Tor Kihlberg , Bengt Langstrom
- Applicant Address: GB Little Chalfont
- Assignee: GE Healthcare Limited
- Current Assignee: GE Healthcare Limited
- Current Assignee Address: GB Little Chalfont
- Main IPC: C07D401/06
- IPC: C07D401/06 ; A61K51/00
![Method for the use of [11 C] carbon monoxide in labeling synthesis of 11C-labelled amides using metal amides and photo-induced free radical carbonylation](/abs-image/US/2012/03/06/US08129528B2/abs.jpg.150x150.jpg)
Abstract:
Methods and reagents for photo-initiated carbonylation with carbon-isotope labeled carbon monoxide using weakly nucleophilic amines and alkyl/aryl iodides are provided. The resultant carbon-isotope labeled amides are useful as radiopharmaceuticals, especially for use in Positron Emission Tomography (PET). Associated kits for PET studies are also provided.
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