The present disclosure provides a display panel driving apparatus that can make the circuit layout surface area smaller, and prevent circuit damage. The display panel driving apparatus includes a source amplifier, a sink amplifier, a switch and the like. The source amplifier includes a first output circuit, a second output circuit and the like, and a guard transistor is provided between the first output circuit and the second output circuit to prevent an output signal voltage of the first output circuit from becoming less than an intermediate voltage. The sink amplifier includes a first output circuit and a second output circuit, and a guard transistor is provided between the first output circuit and the second output circuit to prevent an output signal voltage of the first output circuit from exceeding an intermediate voltage.