An apparatus and method for interference cancellation is provided to cancel the interference such as echo and cross-talk received by a receiver of a communication system. The apparatus includes a digital cancellation signal generator, a first canceller, and a second canceller. The digital cancellation signal generator can generate a digital cancellation signal, which includes a first and a second portion and represents an interference signal within a received signal. The first canceller can perform an analog cancellation on the received signal to output a partially-interference-canceled received signal according to the first portion of the digital cancellation signal. The second canceller can perform a digital cancellation on the partially-interference-canceled received signal according to the second portion of the digital cancellation signal.