Invention Grant
US08133666B2 Method for identifying agents capable of inhibiting APOBEC3C activity in HIV-infected cells
有权
鉴定能够抑制HIV感染细胞中APOBEC3C活性的试剂的方法
- Patent Title: Method for identifying agents capable of inhibiting APOBEC3C activity in HIV-infected cells
- Patent Title (中): 鉴定能够抑制HIV感染细胞中APOBEC3C活性的试剂的方法
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Application No.: US11577077Application Date: 2005-10-31
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Publication No.: US08133666B2Publication Date: 2012-03-13
- Inventor: Robert M. Grant , Khaoula Bourara
- Applicant: Robert M. Grant , Khaoula Bourara
- Applicant Address: US CA San Francisco
- Assignee: The J. David Gladstone Institutes
- Current Assignee: The J. David Gladstone Institutes
- Current Assignee Address: US CA San Francisco
- Agency: Bozicevic, Field & Francis LLP.
- Agent Paula A. Borden
- International Application: PCT/US2005/039522 WO 20051031
- International Announcement: WO2006/065377 WO 20060622
- Main IPC: C12Q1/70
- IPC: C12Q1/70 ; A61K39/21
Abstract:
The present invention provides methods of identifying agents that reduce a level of active APOBEC3C in a cell. The present invention provides agents that reduce a level of active APOBEC3C in a cell; and compositions comprising the agents. The present invention further provides methods of reducing the mutation rate of a lentivirus in a cell; and methods of reducing the emergence of drug-resistant strains of lentivirus. The present invention further provides methods for treating lentivirus infections.
Public/Granted literature
- US20090105187A1 METHODS OF TREATING LENTIVIRUS INFECTION Public/Granted day:2009-04-23
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