Invention Grant
US08133679B2 Methods of identifying agents that diminish cellular toxicity associated with an α-synuclein polypeptide of Parkinson's disease in yeast
有权
识别在酵母中减少与帕金森病的α-突触核蛋白多肽相关的细胞毒性的试剂的方法
- Patent Title: Methods of identifying agents that diminish cellular toxicity associated with an α-synuclein polypeptide of Parkinson's disease in yeast
- Patent Title (中): 识别在酵母中减少与帕金森病的α-突触核蛋白多肽相关的细胞毒性的试剂的方法
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Application No.: US12272031Application Date: 2008-11-17
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Publication No.: US08133679B2Publication Date: 2012-03-13
- Inventor: Paul J. Muchowski , Susan L. Lindquist , Tiago Outeiro
- Applicant: Paul J. Muchowski , Susan L. Lindquist , Tiago Outeiro
- Applicant Address: US MA Cambridge US WA Seattle
- Assignee: Whitehead Institute for Biomedical Research,University of Washington
- Current Assignee: Whitehead Institute for Biomedical Research,University of Washington
- Current Assignee Address: US MA Cambridge US WA Seattle
- Agency: Fish & Richardson P.C.
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; G01N33/53 ; G01N33/569 ; A01N63/00 ; A01N63/04 ; C07H21/04 ; C12N15/11
Abstract:
Methods of screening candidate agents to identify lead compounds for the development of therapeutic agents for the treatment of a neurodegenerative disease, such as Huntington's Disease and Parkinson's Disease and methods for identifying a mutation in, or changes in expression of, a gene associated with neurodegenerative disease, such as Huntington's Disease and Parkinson's Disease, are provided.
Public/Granted literature
- US20090068111A1 METHODS OF IDENTIFYING LEAD COMPOUNDS THAT MODULATE TOXICITY OF NEUROTOXIC POLYPEPTIDES Public/Granted day:2009-03-12
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