A system and method are provided for multiple nodes to wirelessly transmit in an Ad-hoc network architecture. First of all, an integration module of the system integrates a multi-node transmission protocol into a reservation column of a data packet. Next, an initial node of the system transmits the integrated data packet. Afterwards, according to the multi-node transmission protocol, one or more bridge node of the system receives the integrated data packet transmitted from the initial node. And finally, according to the multi-node transmission protocol, a destination node of the system receives the integrated data packet transmitted from the bridge node. By means of the proposed system and method, data transmission between multiple nodes is achieved under the Ad-hoc network architecture.