A method to identify a Region Of Interest (ROI) within an image includes the steps of: reading a digital image; finding predetermined brightness values; analyzing lines near a plurality of outer edges of the digital image; identifying an entire area of the digital image as the ROI if the found brightness values are also found in lines near the plurality of outer edges of the digital image; computing Radon transforms to generate one dimensional (1D) projections of the digital image if the found brightness values are not found in the lines; detecting a set of edges within the 1D projections; selecting edges from the set of edges; validating the selected edges to identify a set of validated edges; computing the ROI from the set of validated edges of the 1D projections; and saving the computed ROI to memory. A system to perform the method is also described.