Methods and systems for WCDMA power amplifier closed loop power control are disclosed and may include determining a magnitude of an output RF signal generated by a power amplifier (PA), and configuring a gain of a PGA coupled to an input of the PA via closed-loop feedback to maintain a desired magnitude of the output RF signal. The closed-loop feedback architecture may include a slot-based and/or a real time-based control. A signal proportional to the output signal may be generated by an envelope detector. The signal generated by the envelope detector may be utilized to generate a root-mean-squared (RMS) value. The gain of the PGA may be configured by comparing the RMS value to a desired magnitude of the output signal over a time slot and/or utilizing a real time error signal generated by subtracting the signal proportional to the magnitude of the output signal from a desired magnitude.