Method, system and computer-readable medium to select monitors that increase the likelihood of detecting prefix hijacking events of a destination prefix are disclosed. The method includes assigning each of the candidate prefix hijack monitors to a respective cluster of a plurality of clusters. Each of the candidate prefix hijack monitors is associated with an autonomous system (AS) that indicates an AS path of autonomous systems (ASes) from the AS to a destination prefix associated with a destination AS. The method further includes iteratively merging a pair of clusters with a highest similarity score amongst cluster pairs of the plurality of clusters into a single cluster until a processed number of clusters is less than or equal to a predetermined number of clusters. The method also includes ranking each candidate prefix hijack monitor of each of the processed number of clusters according to a route type from an AS associated with the candidate prefix hijack monitor and an AS distance from the AS associated with the candidate prefix hijack monitor to the destination AS. Yet further, the method includes determining a highest ranked candidate prefix hijack monitor of each of the processed number of clusters.