Invention Grant
- Patent Title: Methods of identifying responders to dopamine agonist therapy and treating metabolic conditions thereof
- Patent Title (中): 鉴定多巴胺激动剂治疗反应者和治疗其代谢状况的方法
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Application No.: US12931859Application Date: 2011-02-11
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Publication No.: US08137992B2Publication Date: 2012-03-20
- Inventor: Anthony H. Cincotta
- Applicant: Anthony H. Cincotta
- Applicant Address: US RI Tiverton
- Assignee: VeroScience LLC
- Current Assignee: VeroScience LLC
- Current Assignee Address: US RI Tiverton
- Agency: Wiggin and Dana LLP
- Agent Todd E. Garabedian
- Main IPC: G01N33/53
- IPC: G01N33/53 ; C12Q1/00 ; A01N61/00 ; A01N43/58 ; A01N43/60 ; A61K31/00 ; A61K31/50 ; A61K31/495 ; G01J3/42 ; G01J3/427 ; G01N13/00 ; G01N30/84
Abstract:
The present invention is directed to a method of identifying patients to be treated by dopamine agonist therapy comprising the step of analyzing a plasma or urine sample from said patient for concentrations of norepinephrine (NE), norepinephrine metabolites (NE metabolites), dopamine, dopamine metabolites, serotonin, serotonin metabolites, or fasting triglycerides, wherein one or more of: (a) NE metabolites, (b) NE/NE metabolites:dopamine/dopamine metabolites, (c) NE and serotonin, (d) NE/NE metabolites and serotonin, (e) NE and serotonin metabolites, (f) NE/NE metabolites and serotonin metabolites, or (g) NE is/are greater than about 30% over normal level; or dopamine/dopamine metabolites are less than about 30% below normal; or fasting triglycerides are greater than about 150 mg/dl and/or said patient has blood pressure of greater than about 135/85 mm Hg. The present invention is also directed to treating identified patients with dopamine agonist therapy.
Public/Granted literature
- US20110136817A1 Methods of identifying responders to dopamine agonist therapy Public/Granted day:2011-06-09
Information query
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