There is described an image sensor based indicia reading terminal comprising a variable setting imaging lens having a first setting at which the terminal has a first plane of optimum focus and a second setting at which the terminal has a second plane of optimum focus. According to one embodiment, a first predetermined picture size where picture size is determined according to a number of pixels subject to read out, can be associated to the first lens setting and a second picture size can be associated to the second lens setting such that the terminal with the lens setting set to the first setting reads out a frame of a first picture size and with the lens setting set to a second setting reads out a frame of a second picture size. In addition to or in place of the picture size operational parameters, different operational parameters can be associated to the respective first and second lens settings. Additionally or alternatively, different processes for determining an operational parameter and/or different algorithms for determining an operational parameter can be associated to each of the first and second lens settings.