A device enables a patient to perform non-invasive punctal occlusion by applying firm pressure to the skin external to the lacrimal canaliculi during the administration of eyedrop medicine, for the purpose of prolonging the medicine retention time. The device of this invention may be adjusted to fit the nasal aspect of the orbital rims where the lacrimal canaliculi are located. The pressure to be applied on the lacrimal canaliculi is adjustable to meet the optimal pressure requirement. The device also has a visual reference attachment that provides visual referencing points for positioning the tip of the eyedrop bottle towards the eyes. This device enables a hands-free operation and does not interfere with the wearing of eyeglasses.