A hand-operated surgical instrument with sequentially engaged tip closing guides. The instrument includes first and second arms having tips that close during a closure operation. A slotted tip closure guide on the arms engages first during the closure operation. A pin closure guide on the arms between the slotted closure guide and the tips engages during the closure operation after the engagement of the slotted closure guide. The sequential engagement of the guides provides precise approximation of the instrument tips and prevents “scissoring” of the tips.