Invention Grant
US08147804B2 Method and device for isolating a chemically and radiochemically cleaned 68Ga-radionuclide and for marking a marking precursor with the 68Ga-radionuclide
有权
用于分离化学和放射性化学清洁的68Ga放射性核素并用68Ga放射性核素标记标记前体的方法和装置
- Patent Title: Method and device for isolating a chemically and radiochemically cleaned 68Ga-radionuclide and for marking a marking precursor with the 68Ga-radionuclide
- Patent Title (中): 用于分离化学和放射性化学清洁的68Ga放射性核素并用68Ga放射性核素标记标记前体的方法和装置
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Application No.: US11719981Application Date: 2005-11-22
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Publication No.: US08147804B2Publication Date: 2012-04-03
- Inventor: Frank Roesch , Dmitry V. Filosofov , Konstantin Zhernosekov , Marc Jennewein
- Applicant: Frank Roesch , Dmitry V. Filosofov , Konstantin Zhernosekov , Marc Jennewein
- Applicant Address: DE Mainz
- Assignee: Johannes Gutenberg-Universität Mainz
- Current Assignee: Johannes Gutenberg-Universität Mainz
- Current Assignee Address: DE Mainz
- Agency: ProPat, L.L.C.
- Priority: DE102004057225 20041126
- International Application: PCT/EP2005/012471 WO 20051122
- International Announcement: WO2006/056395 WO 20060601
- Main IPC: A61K49/04
- IPC: A61K49/04
Abstract:
The invention relates to initial 68Ge/Ga-generator elute which is guided directly to a cation exchanger, whereon 68Ga is quantitatively absorbed and is cleaned simultaneously in a chemical and radio chemical manner. Subsequently, the 68Ga-radio nuclide is combined with a radio pharmaceutical substance by a marking precursor made of a ligand or a peptide or a protein which is cross-linked in a covalent manner to a ligand.
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