Invention Grant
- Patent Title: CD20-binding polypeptide compositions and methods
- Patent Title (中): CD20结合多肽组合物和方法
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Application No.: US10917599Application Date: 2004-08-13
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Publication No.: US08147832B2Publication Date: 2012-04-03
- Inventor: Francis Joseph Carr , Stephen Williams , Stephen D. Gillies
- Applicant: Francis Joseph Carr , Stephen Williams , Stephen D. Gillies
- Applicant Address: DE Darmstadt
- Assignee: Merck Patent GmbH
- Current Assignee: Merck Patent GmbH
- Current Assignee Address: DE Darmstadt
- Agency: Olson & Cepuritis, Ltd.
- Main IPC: C07K19/00
- IPC: C07K19/00 ; C07K16/28 ; C07K16/30 ; A61K39/395
Abstract:
A CD20-binding polypeptide composition comprising a combination of a modified heavy chain variable region polypeptide and a modified light chain variable region polypeptide. The combination can be (a) a modified 2B8 antibody heavy chain variable region polypeptide of SEQ ID NO: 48; and a modified 2B8 antibody light chain variable region polypeptide of SEQ ID NO: 49; or (b) a modified Leu16 antibody heavy chain variable region polypeptide of SEQ ID NO: 50; and a modified Leu16 antibody light chain variable region polypeptide of SEQ ID NO: 51.
Public/Granted literature
- US20050069545A1 CD20-Binding polypeptide compositions and methods Public/Granted day:2005-03-31
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