Invention Grant
US08147837B2 Use of mycobacterial mannosylated lipoglycans peptide mimotopes for treating inflammation
有权
使用分枝杆菌甘露糖基脂聚糖肽模拟表位来治疗炎症
- Patent Title: Use of mycobacterial mannosylated lipoglycans peptide mimotopes for treating inflammation
- Patent Title (中): 使用分枝杆菌甘露糖基脂聚糖肽模拟表位来治疗炎症
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Application No.: US11630115Application Date: 2005-06-23
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Publication No.: US08147837B2Publication Date: 2012-04-03
- Inventor: Herve Bercovier , Ayelet Barenholz
- Applicant: Herve Bercovier , Ayelet Barenholz
- Applicant Address: IL Jerusalem
- Assignee: Yissum Research Development Company of The Hebrew University of Jerusalem
- Current Assignee: Yissum Research Development Company of The Hebrew University of Jerusalem
- Current Assignee Address: IL Jerusalem
- Agent Susanne M. Hopkins; Ari G. Zytcer
- International Application: PCT/IL2005/000674 WO 20050623
- International Announcement: WO2006/001011 WO 20060105
- Main IPC: A61K39/00
- IPC: A61K39/00

Abstract:
The present invention is based on the discovery that biological peptide-based mimotopes of mannose-containing cell-wall compounds of Mycobacterium tuberculosis, specifically, ManLAM, have an anti-inflammatory effect and immunoregulator effect in animal models of inflammation. Such models include animal models of allergic peritonitis, allergic asthma and septic shock model (mice injected with LPS) and in Crohn's disease model (TNBS-induced colitis). Thus, the present invention concerns the use a molecule, particularly, an amino acid based molecule for the production of a pharmaceutical composition for the treatment of an inflammatory condition, the amino acid comprising one or more peptides characterized in that it can bind to ManLAM binding antibodies; and/or it can elicit an immune response in a subject inoculated therewith, giving rise to production of ManLAM-binding antibodies. The invention also provides pharmaceutical compositions for treating inflammatory conditions and comprising the amino acid-based molecule, as well as to methods of treatment of such conditions by administering to a subject an amount of the amino-acid based molecules.
Public/Granted literature
- US20080318868A1 Use of Mycobacterial Mannosylated Lipoglycans Peptide Mimotopes For Treating Inflammation Public/Granted day:2008-12-25
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