Invention Grant
US08147844B1 Mpl ligand (thrombopoietin), nucleic acids encoding such, and methods of treatment using mpl ligand
失效
Mpl配体（血小板生成素），编码此的核酸以及使用mpl配体的治疗方法
- Patent Title: Mpl ligand (thrombopoietin), nucleic acids encoding such, and methods of treatment using mpl ligand
- Patent Title (中): Mpl配体（血小板生成素），编码此的核酸以及使用mpl配体的治疗方法
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Application No.: US08374540Application Date: 1994-12-28
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Publication No.: US08147844B1Publication Date: 2012-04-03
- Inventor: Dan L. Eaton , Frederic J. de Sauvage
- Applicant: Dan L. Eaton , Frederic J. de Sauvage
- Applicant Address: US CA South San Francisco
- Assignee: Genentech, Inc.
- Current Assignee: Genentech, Inc.
- Current Assignee Address: US CA South San Francisco
- Agency: Merchant & Gould P.C.
- International Application: PCT/US94/14553 WO 19941228
- International Announcement: WO95/18858 WO 19950713
- Main IPC: C07H21/04
- IPC: C07H21/04 ; C12N15/12 ; C12N15/19 ; C07K14/52 ; A61K38/19
Abstract:
Isolated thrombopoietin (TPO), isolated DNA encoding TPO, and recombinant or synthetic methods of preparing and purifying TPO are disclosed. Various forms of TPO are shown to influence the replication, differentiation or maturation of blood cells, especially megakaryocytes and megakaryocyte progenitor cells. Accordingly, these compounds may be used for treatment of thrombocytopenia.
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