Invention Grant
- Patent Title: Coated pellets
- Patent Title (中): 涂层颗粒
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Application No.: US12483646Application Date: 2009-06-12
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Publication No.: US08147874B2Publication Date: 2012-04-03
- Inventor: Iris Ziegler , Irwin Jacobs
- Applicant: Iris Ziegler , Irwin Jacobs
- Applicant Address: DE Aachen
- Assignee: Gruenenthal GmbH
- Current Assignee: Gruenenthal GmbH
- Current Assignee Address: DE Aachen
- Agency: Crowell & Moring LLP
- Priority: DE102006059510 20061214
- Main IPC: A61K9/14
- IPC: A61K9/14 ; A61K9/28 ; A61K9/34 ; A61K9/42

Abstract:
Coated pellets which comprise an active pharmaceutical ingredient that is poorly soluble in water, release at least 80% of the active ingredient under in vitro conditions in phosphate buffer at pH 5.0 after 30 minutes and are bioequivalent to a liquid formulation of the active ingredient under in vitro fed status test conditions and/or are coated with a composition, which includes a lipophilic component (A) and a hydrogel former (B), wherein the pure lipophilic component (A) has (i) an HLB value of ≦5, and/or (ii) a melting range of ≧60° C., and/or (iii) a solidification range Δ of less than 35° C., and/or (iv) a density of ≧0.80 g cm−3.
Public/Granted literature
- US20100068290A1 COATED PELLETS Public/Granted day:2010-03-18
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